This entry represents the centrosomal protein of 19kDa (CEP19, also known as C3orf34) from eukaryotes. It was identified by complementary proteomics methods []. It associates with the mother centriole in early interphase. It localises to spindle poles during mitosis, and to distinct foci oriented towards the midbody at telophase []. Its function is not clear.
This entry includes Spd2 (spindle-defective protein 2) from Caenorhabditis elegans, CEP192 (centrosomal protein of 192kDa) from humans, and homologues from metazoa and fungi. Spd2 is required both for centrosome duplication and maturation [, , ]. CEP19 is required for mitotic centrosome and spindle assembly []. They are required for pericentriolar material (PCM) recruitment [, , ].
