This family of proteins is found in eukaryotes. There is a single completely conserved residue D that may be functionally important. The family includes CFAP276 and homologues. Bovin CFAP276 has been identified as a microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating []. Members of this family have been suggested to be involved in intracellular Ca2 homeostasis [].
