CHRNB2 is a subunit of the neuronal nicotinic acetylcholine receptor. After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane permeable to sodium ions [].Acetylcholine receptors (AChRs) consist of two major subtypes: the metabotropic muscarinic receptors and the ionotropic nicotinic receptors (nAChRs). Both share the property of being activated by the neurotransmitter acetylcholine (ACh), and they are expressed by both neuronal and nonneuronal cells throughout the body []. Multiple subunits have been identified for the nicotinic acetylcholine receptors (nAChRs). Mutations in CHRNB2 are associated with epilepsy [].
