This entry represents carbohydrate sulphotransferase, which catalyses the transfer of a sulphate to position 6 of the galactose (Gal) residues in keratan. It may function in the sulphation of sialyl N-acetyllactosamine oligosaccharide chains attached to glycoproteins and participate in the biosynthesis of selectin ligands. Selectin ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Carbohydrate sulphotransferase CHST1, CHST2, CHST3, and CHST4 are all involved in producing functional L-selectin ligands [].Deficiency of CHST3 (also known as chondroitin-6-sulphotransferase) has been associated with severe chondrodysplasia with progressive spinal involvement []. Macular corneal dystrophy (MCD) has also been shown to be caused by mutations in the carbohydrate sulphotransferase 6 gene (CHST6) [].
