Cyclic nucleotide-gated cation channel beta-1 (CNGB1, also known as CNG4 or GARP) is a beta subunit of the cyclic nucleotide-gated (CNG) channel. CNG channels control the influx of Ca2+and Na+ in response to signal-induced changes of cGMP or cAMP levels. They play a key role in olfactory and visual transduction []. CNGB1 has a splice variant known as GARP2, which is a high affinity rod photoreceptor phosphodiesterase (PDE6)-binding protein that modulates its catalytic properties [].
