The CCR4-NOT complex plays a key role in mRNA decay in all eukaryotes, thereby contributing importantly to gene expression regulation []. Human C2ORF29 proteins, also known as CNOT11, is a component of the CCR4-NOT complex. CNOT11 interacts with the first amino acids of CNOT1 and with CNOT10 and is required for the association of CNOT10 with the CCR4-NOT complex [].