CREBRF, also known as LRF, recruits CREB3 (also known as Luman) into nuclear foci and represses CREB3-mediated activation of UPRE (unfolded protein response element)-containing promoters []. CREB3 is implicated in herpes simplex virus-1 (HSV-1) latency/reactivation and the unfolded protein response (UPR) pathway []. Homologues are found predominantly in metazoa.