CstF1 (also known as CstF-50) is a cleavage stimulation factor required for polyadenylation and 3'-end cleavage of pre-mRNAs []. This entry also includes CstF1 homologues from plants.
This entry represents the dimerisation domain found at the N terminus of cleavage stimulation factor subunit 1 (CSTF1) from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The Cleavage stimulation Factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the Cleavage and Polyadenylation Specificity Factor (CPSF) at the polyadenylation site as required for productive RNA cleavage [].
This entry represents the dimerisation domain found at the N terminus of cleavage stimulation factor subunit 1 (CSTF1) from eukaryotes. This domain allows for homodimerisation such that the functional state of CSTF1 is a heterohexamer. The Cleavage stimulation Factor (CstF) complex is composed of three subunits and is essential for pre-mRNA 3'-end processing. CstF recognises U and G/U-rich cis-acting RNA sequence elements and helps to stabilise the Cleavage and Polyadenylation Specificity Factor (CPSF) at the polyadenylation site as required for productive RNA cleavage [].
