CUE domain containing 2 (CUEDC2) is involved in the regulation of the cell cycle, inflammation, and tumorigenesis []. It interacts with progesterone receptor (PR) and promotes progesterone-induced PR degradation by the ubiquitin-proteasome pathway []. It also interacts with SOCS1 to to suppress SOCS1's ubiquitin-mediated degradation [].
CUEDC2 is a novel negative regulator of progesterone receptor (PR) and functions to promote the progesterone-induced PR degradation by the ubiquitin-proteasome pathway []. It also acts as the regulator of JAK1/STAT3 signaling through inhibiting cytokine-induced phosphorylation of JAK1 and STAT3 and the subsequent STAT3 transcriptional activity []. This entry represents the CUE domain found in CUEDC2.
