DAB-2 interacting protein (Dab2IP) is a GTPase activating protein involved in the regulation of multiple signalling pathways. Dab2IP regulates PI3K-AKT signalling and functions as a tumour suppressor. It modulates the balance between phosphatidylinositol 3-kinase (PI3K) mediated cell survival and ASK1 mediated apoptosis [, ]. Besides its function as a tumour suppressor, Dab2IP is also highly expressed in the brain, where it interacts with Dab1 (Disabled homologue 1), a key mediator of the Reelin pathway that controls several aspects of brain development and function [, , ]. It also functions as an inhibitor in VEGFR2-mediated adaptative angiogenesis [].Dab2IP has been associated with metastatic prostate cancer [], abdominal aortic aneurysms []and coronary heart disease [].
