This entry represents a group of WD repeat-containing proteins, including DCAF7 from animals, LWD1/2/TTG1 from Arabidopsis and YPL247C from budding yeasts. In general, WD40 repeat domain-containing proteins are scaffolding elements for the assembly of multi-subunit protein complexes. DCAF7, also known as WDR68, interacts with Dual-specificity Tyrosine Phosphorylation-Regulated Kinase 1A (DYRK1A, a Down's syndrome-associated protein kinase) []and is required for Endothelin-1 (EDN1) signalling []. It also acts as a DDB1- and CUL4-associated factor []. Mutations in the DCAF7 gene have been linked to cleft lip with or without cleft palate (CL/P) []. In Arabidopsis, LWD1 and LWD2 serve as clock proteins involved in photoperiod flowering control []. TRANSPARENT TESTA GLABRA 1 (TTG1) is a regulator of early developmental traits and is also involved in flowering time regulation [].
