DEAH-box helicase 15 (DHX15) is a pre-mRNA processing factor involved in disassembly of spliceosomes after the release of mature mRNA []. DHX15 belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding [].Thisentry represents the DEXH-box helicase domain of DHX15. This domain contains the ATP-binding region.
NudCD1, also known as CML66 or OVA66, belongs to the NudC family, whose members share a conserved p23 domain. It is the more distant and less characterised family member. NudCD1 is a tumour associated antigen highly expressed in human leukaemia, some solid tumours and tumour cell lines []. Its expression in normal tissues is restricted to testis [, ]. Different NudCD1 isoforms have unique interacting partners, with the first isoform binding to a putative RNA helicase named DHX15 involved in mRNA splicing [].
