The human death-inducer obliterator (Dido) gene encodes three splicing variants: Dido1, 2, and 3 []. Dido1 is a putative transcription factor that plays an important role in regulating embryonic stem cell maintenance []. It has been implicated in apoptosis and development [, ]and is a tumour suppressor []. The isoform Dido3 is a nuclear protein that forms part of the spindle assembly checkpoint (SAC) and is necessary for correct chromosome segregation in somatic and germ cells []. The plant homeodomain (PHD) finger of Dido3 has been shown to modulate cell differentiation and division [].
