This entry includes Dr1 homologues from plants. They are putative transcription factors. Human Dr1 has been shown to interact with TATA-binding protein (TBP) and block its ability to activate transcription []. Arabidopsis Dr1 may affect the regulatory pathway for sexual development [].
ZZ-type zinc finger-containing protein 3 (ZZZ3) is a component of the ATAC complex []. ZZZ3 contains an HTH myb-type domain (PDB:2YUM) and a ZZ-type zinc-finger (PDB:2FC7).The human ADA2A-containing complex (ATAC) is a histone acetyltransferase acting on histones H3 and H4 that is similar to but distinct from a similar complex initially identified in Drosophila melanogaster. The ATAC complex iscomposed of KAT14, KAT2A, TADA2L, TADA3L, ZZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 [].
Cysteine-rich protein 2-binding protein (KAT14) is a component of the ATAC complex. KAT14 may be the scaffold that stabilizes the complex [].The human ADA2A-containing complex (ATAC) is a histone acetyltransferase acting on histones H3 and H4 thatis similar to but distinct from a similar complex initially identified in Drosophila melanogaster. The ATAC complex is composed of KAT14, KAT2A, TADA2L, TADA3L, ZZZ3, MBIP, WDR5, YEATS2, CCDC101 and DR1 [].
