Destrin (Dstn) is an actin depolymerising factor that maintains a homeostatic ratio of actin in two forms, filamentous actin (F-actin) and globular actin (G-actin). It severs actin filaments (F-actin) and binds to actin monomers (G-actin). Mutations in Destrin gene lead to abnormalities in the structure and function of the cornea and subsequent blindness in mice [, ].
