D-aminoacyl-tRNA deacylase (also known as D-tyrosyl-tRNA deacylase or DTD) helps cells to counteract the accumulation of harmful D-aminoacyl-tRNAs by removing D-aminoacyl moieties from the 3'-end of tRNA. Three distinct deacylases have been discovered: DTD1 is predicted to occur in most bacteria and eukaryotes, DTD2 has homologues in most archaea and in plants, and DTD3 is found in cyanobacteria [].This entry represents DTD3. DTD3 behaves as a metalloenzyme and has been shown to confer resistance against D-tyrosine [].
