Human YVH1, also known as dual specificity phosphatase 12 (DUSP12), is a cell survival phosphatase that prevents both thermal and oxidative stress-induced cell death. Furthermore, it associates with multiple ribonucleoprotein particles and may affect a variety of fundamental cellular processes []. The enzyme is known as dual specificity protein phosphatase MPK-4 in Drosophila[]. Yeast YVH1, on the other hand, is required for a late maturation step in the 60S biogenesis pathway [].
