Eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), also known as PKR, is an IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection [, , , ]. It is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation [, ]. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs).This entry represents the first DSRM of EIF2AK2.
Eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2), also known as PKR, is an IFN-induced dsRNA-dependent serine/threonine-protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (EIF2S1/eIF-2-alpha) and plays a key role in the innate immune response to viral infection [, , , ]. It is also involved in the regulation of signal transduction, apoptosis, cell proliferation and differentiation [, ]. EIF2AK2 proteins contain two to three double-stranded RNA binding motifs (DSRMs).This entry represents the second DSRM of EIF2AK2.
