Elf4 or MEF (myeloid Elf-1-like factor) is an ETS transcription factor that activates innate immunity-associated genes such as lysozyme [], human beta-defensin 2 [], interleukin-8 (IL-8) [], and type I interferon []. It plays a role in the development and function of natural killer and NK T-cells []. Elf4/MAF has oncogenic properties and contributes to malignant transformation by inhibiting both the p53 and p16/Rb pathways [, ]. It also promotes the transition of cells from G1 to S phase and enhances the movement of hemapotoietic stem cells out of a quiescent state (G0 phase) into the cell cycle [, ].
Protein EARLY FLOWERING 4 is a component of the central CCA1/LHY-TOC1 feedback loop in the circadian clock that promotes clock accuracy and is required for sustained rhythms in the absence of daily light/dark cycles [, ].This domain forms an α-helical homodimer in ELF4 proteins.
Cold-regulated proteins 27 and 28 are regulated by low temperature and light. They are involved in central circadian clock regulation and in flowering promotion, by binding to the chromatin of clock-associated evening genes TOC1, PRR5, ELF4 and cold-responsive genes in order to repress their transcription [, ]. They are also involved in freezing tolerance regulation.
This entry represents a group of plant Myb domain proteins, including LUX, BOA and MYBC1 from Arabidopsis. LUX and BOA are transcription factors and critical components of the regulatory circuit of the circadian clock [, ]. LUX also binds toELF3 and associates with ELF4 in a diurnal complex which is required for the expression of the growth-promoting transcription factors PIF4 and PIF5 and subsequent hypocotyl growth in the early evening []. MYBC1 has been shown to negatively regulate freezing tolerance in Arabidopsis [].
Elf (E74-like-factor) is a subfamily of the ETS transcription factor family []. Elf-1 is an immune cell specific transcription factor. It is found in T cells, B cells, megakaryocytes,and mast cells and is involved in the control of transcription for various immune proteins []. Included in the Elf subfamily are also Elf-2 (NERF) []and Elf4 (MEF) [].This entry represents a domain found in the N terminus of Elf transcription factors. It is approximately 110 amino acids in length and is found in association with . It contains a conserved PAVIVE sequence motif.
