EMC3 is a subunit if the ER Membrane protein Complex (EMC), which is required for efficient folding of proteins in the endoplasmic reticulum (ER). Loss of the EMC leads to accumulation of misfolded membrane proteins [].
This entry represents uncharacterized proteins from archaea, including protein MJ0935 from Methanocaldococcus jannaschii . These proteins are related to the eukaryote integral membrane proteins EMC3 and TMCO1-like. The structure has been solved for protein MJ0480 also from M. jannaschii, which has four transmembrane helices. It has been suggested that archaeal proteins may function as insertases of the archaeal plasma membrane [].
