Ectonucleotide pyrophosphatase/phosphodiesterase family member 4 (ENPP4), also known as bis(5'-adenosyl)-triphosphatase, has a role in stimulating platelet aggregation and secretion. This procoagulant enzyme hydrolases diadenosine triphosphate Ap3A into AMP and ADP, providing a source of ADP necessary to sustain the clotting reaction at the site of the growing thrombus [].
