This entry represents a family of fatty acid hydroxylases, including Scs7 from budding yeasts and FA2H from animals and plants. They contain an N-terminal Cytochrome b5-like heme/steroid binding domain. Scs7 is a sphingolipid alpha-hydroxylase involved in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids []. Human FA2H is required for alpha-hydroxylation of free fatty acids and the formation of alpha-hydroxylated sphingolipids []. It is is responsible for the formation of alpha-hydroxylated ceramide in oligodendrocytes of the mammalian brain [].
