Protein FAM3B is a member of the family with sequence similarity 3 (FAM3) super family []. It also known as cytokine-like protein 2-21 or pancreatic-derived factor (PANDER), as it strongly expressed from the endocrine pancreas []. PANDER is a hormone that regulates glucose levels via interaction with both the endocrine pancreas and liver. It is regulated by both glucose and insulin and may have a role in the regulation or facilitation of insulin secretion [].
Family with sequence similarity 3 (FAM3) members are designated as FAM3A, FAM3B, FAM3C and FAM3D. Thereis increasing evidence that FAM3A, FAM3B and FAM3C are important regulators of glucose and lipid metabolism, which makes this family a promising therapeutical target for non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes [].
