FATE1 is a member of the Miff protein family, whose members are involved in the control of mitochondrial and peroxisomal fission. It is localized in mitochondria associated ER membranes (MAM) and is implicated in the regulation of Ca2+ and drug-dependent apoptosis in cancer cells by modulating ER-mitochondria distance []. Homologues are found only in chordates.
This entry represents a domain found in mitochondrial fission factor (Mff) and at the C terminus of FATE1. This domain has a predicted transmembrane segment preceded by a coiled-coil region. Despite their similarity in the C terminus, FATE1 lacks a Mff-similar N-terminal domain that is essential for interaction of Mff with the dynamin-related GTPase Drp1, which mediates mitochondrial fission. Instead, FATE1 is involved in the regulation of ER-mitochondria distance and Ca(2+) uptake by mitochondria [].
