F-box only protein 11 (FBXO11) is a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex, which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. This entry includes FBXO11 from vertebrates and its homologue, DRE-1 from invertebrates [, ].