Proteins in this entry contain a fido domain. The domain is named after the Fic and Doc proteins where it is found. Included in this entry are adenosine monophosphate-protein transferase Fic and FICD. Both Fic and FICD add adenosine 5'-monophosphate (AMP) to specific residues of target proteins (AMPylation), or remove the same modification from target proteins (de-AMPylation), depending on whether cells are in a resting state or stressed []. Both bind divalent cations, preferring Mn2+over Mg2+[]. The adenosine monophosphate-protein transferase SoFic from Shewanella oneidensis is known only to add AMP to target proteins, either at Tyr or Thr residues [].
