Transcription factor activator protein (AP)-1, comprising Jun (c-Jun, JunB, and JunD) and Fos (c-Fos, FosB, Fra1, and Fra2) family members, plays a central role in regulating gene transcription in various biological processes []. Fos protein family members form stable heterodimerswith Jun proteins and thereby enhance their DNA-bindingactivity []. This entry reprsents FosB []. FosB-null mice display impaired adult hippocampal neurogenesis and spontaneous epilepsy with depressive behavior [].
FosB is a metallothiol transferase which confers resistance to the antiobiotic fosfomycin by catalyzing the addition of a thiol cofactor to fosfomycin []. L-cysteine is thought to be the physiological thiol donor.
Glyoxalase I () (lactoylglutathione lyase) catalyzes the first step of the glyoxal pathway. S-lactoylglutathione is then converted by glyoxalase II to lactic acid [].Glyoxalase I is an ubiquitous enzyme which binds one mole of zincper subunit. The bacterial and yeast enzymes are monomeric while the mammalian one is homodimeric. The sequence of glyoxalase I is well conserved.The domain represented by this entry is found in glyoxalase I and in other related proteins, including fosfomycin resistance proteins FosB [], FosA [], FosX []and dioxygenases (eg. 4-hydroxyphenylpyruvate dioxygenase).
