Ferric Chelate Reductase 1 Like protein (FRRS1L) interacts with both GluA1 and GluA2 subunits of AMPA receptors (AMPARs). It plays an important role in the regulation of excitatory synaptic strength []. Mutations in the FRRS1L gene cause epileptic encephalopathy, early infantile, 37 (EIEE37), a form of epileptic encephalopathy, a heterogeneous group of severe childhood onset epilepsies characterised by refractory seizures, neurodevelopmental impairment, and poor prognosis [, ].
