Fascins are actin cross-linking proteins that function in the organisation of two major forms of actin-based structures: dynamic, cortical cell protrusions and cytoplasmic microfilament bundles [].In humans there are three fascin isoforms identified: fascin1-3. Fruit flies only have one fascin, also known as protein singed, which links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis [].This entry represents fascin-1 (FSCN1) from mammals and its homologues from Xenopus laevis and Drosophila melanogaster. FSCN1 plays a role in stress fibre organisation and focal adhesion disassembly []. In humans, FSCN1 serves as a tumour marker that is highly expressed in numerous types of cancer, including lymphomas. It is important for migration and metastasis of tumour cells [].
This entry represents fascin (FSCN) and its homologues, including FSCN1/2/3 from mammals and protein singed from fruit flies. Fascin is a globular actin cross-linking protein, which functions in forming parallel actin bundles in cell protrusions that are key specialisations of the plasma membrane for environmental guidance and cell migration []. Human FSCN1 organises filamentous actin into bundles with a minimum of 4.1:1 actin/fascin ratio. Overexpression of fascin has been linked to a more aggressive clinical course of cancer [].
