Gcn1 acts as a translation activator that mediates translational control by regulating Gcn2 kinase activity. The eIF2alpha kinase Gcn2 is activated under stress conditions by a mechanism involving Gcn2 binding to activator protein Gcn1 [, ]. Phosphorylation of eIF2alpha results in general protein synthesis repression and increased translation of specific mRNAs. Protein ILITYHIA from Arabidopsis is involved in immunity against bacterial infection and in non-host resistance []and is required for the bacterium-triggered stomatal closure response [].
This domain is found in the N-terminal region of Gcn1 protein, which acts as a translation activator that mediates translational control by regulating Gcn2 kinase activity [].
