Proteins containing this domain include lysophosphatidylcholine acyltransferase 1 (LPCAT1) and related proteins. LPCAT1 exhibits acyltransferase activity [], []and is involved in LD (lipid droplet)-associated lipid metabolism [, ]. Proteins containing this domain also includes glycerol-3-phosphate acyltransferases, such as GPAT3 and GPAT4, which are involved in de novo triacylglycerol synthesis [, ].
This entry represents the Glycerol-3-phosphate O-acyltransferase/dihydroxyacetone phosphate acyltransferase (GPAT/DAPAT) family. This entry includes PlsB, a GPAT from E. coli in which membrane synthesis depends on allosteric control of this enzyme. PlsB regulation plays an important role in the phospholipid synthesis pathway and is part of the response to certain stress signals []. In many other bacteria, PlsB is not found, and appears to be replaced by a two enzyme system for 1-acyl-glycerol-3-phosphate biosynthesis, the PlsX/Y system [, ].GPATs are classified into four isoforms in mammals; GPAT1 and GPAT2 are localized in the mitochondrial outer membrane, whereas GPAT3 and GPAT4 are localized in the endoplasmic reticulum membrane []. This entry includes the mitochondrial isoform, GPAT1 and GPAT2.Dihydroxyacetonephosphate acyltransferase (DHAPAT) catalyses the first step in the biosynthesis of ether phospholipid plasmalogen, and may play also a significant role in nonether glycerolipid biosynthesis [, ]. In humans, mutations in DHAPAT results in the genetic disorder rhizomelic chondrodysplasia punctata type 2, characterised by rhizomelic shortening of femur and humerus, cataract,and severe mental retardation [].
This entry represents the C-terminal domain of glycerol-3-phosphate acyltransferases (GPATs) and dihydroxyacetone phosphate acyltransferases.Dihydroxyacetonephosphate acyltransferase (DHAPAT) catalyses the first step in the biosynthesis of ether phospholipid plasmalogen, and may play also a significant role in nonether glycerolipid biosynthesis [, ]. In humans, mutations in DHAPAT results in the genetic disorder rhizomelic chondrodysplasia punctata type 2, characterised by rhizomelic shortening of femur and humerus, cataract,and severe mental retardation [].This entry includes PlsB, a GPAT from E. coli in which membrane synthesis depends on allosteric control of this enzyme. PlsB regulation plays an important role in the phospholipid synthesis pathway and is part of the response to certain stress signals []. In many other bacteria, PlsB is not found, and appears to be replaced by a two enzyme system for 1-acyl-glycerol-3-phosphate biosynthesis, the PlsX/Y system [, ].GPATs are classified into four isoforms in mammals; GPAT1 and GPAT2 are localized in the mitochondrial outer membrane, whereas GPAT3 and GPAT4 are localized in the endoplasmic reticulum membrane []. This entry includes the mitochondrial isoform GPAT.
