GPN-loop GTPase 3 (Gpn3) belongs to the GPN-loop GTPase family []. Budding yeast Gpn3 plays a role in biogenesis of RNA pol II and polIII []and is involved in sister chromatid cohesion []. Its human homologue, Parcs (pro-apoptotic protein is required for cell survival), is a dual regulator of cell proliferation and Apaf-1 function []. Parcs is also required for the nuclear accumulation of RNA polymerase II [].
Proteins in this entry belong to the GPN-loop GTPase family [], including Npa3 (also known as Gpn1) and Gpn2/3 from budding yeasts. In humans, Npa3 homologue is known as XAB1; Gpn2 is known as GPN2/ATPBD1B; Gpn3 is known as Parcs. Npa3 plays an important part in transporting RNA polymerase II (RNAPII) to the nucleus. The binding of Npa3 with RNAPII is GTP-dependent []. Gpn2 and Gpn3 are putative GTPase that have a role in biogenesis of RNA polymerase II and III []. Npa3, Gpn2 and Gpn3 is involved in sister chromatid cohesion [, ].
