The gamma-secretase-activating protein (GSAP) family includes the mammalian GSAPs and the insect pigeon proteins (also known as linotte proteins). GSAP is a gamma-secretase regulator. It specifically activates the production of beta-amyloid protein through interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment (APP-CTF) []. This has led to interest in the protein as potential therapeutic target for the treatment of Alzheimer's disease []. Pigeon/linotte was initially identified as a gene that functions in adult Drosophila during associative learning [].This entry represents a domain found in the C-terminal of GSAP family members.
This entry represents the gamma-secretase-activating protein (GSAP) family, whose members include the mammalian GSAPs and the insect pigeon proteins (also known as linotte proteins). GSAP is a gamma-secretase regulator. It specifically activates the production of beta-amyloid protein through interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment (APP-CTF) []. This has led to interest in the protein as potential therapeutic target for the treatment of Alzheimer's disease []. Pigeon/linotte was initially identified as a gene that functions in adult Drosophila during associative learning [].
