OPI10 family members include protein Hikeshi from vertebrates and protein Opi10 from yeasts. Hikeshi protein acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress; it acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus [].Budding yeast Opi10 is a repressor of the phospholipid biosynthetic genes and specifically binds PA in the endoplasmic reticulum [].
This entry represents a domain found in the human protein Hikeshi and its orthologues OPI10 from other eukaryotes. Hikeshi acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress; it acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus []. This entry covers both the dimerisation and jelly roll domains [, ].
