Proteins in the HIN-200 family are induced by type I and II interferons (IFN), and they are involved in inflammation and immune responses []. In addition to this role in interferon biology, they function as regulators of cell proliferation and differentiation [, ]. This family includes human IFI16, myeloid cell nuclear differentiation antigen, absent in melanoma 2 (AIM2), pyrin and HIN domain-containing protein 1 (IFIX), and murine proteins Ifi202, Ifi203, Ifi204, Ifi205 and Ifi206. All HIN-200 proteins, with the exception of p202, have an N-terminal α-helical PAAD/DAPIN/Pyrin domain [].
