Intraflagellar transport (IFT) is the bidirectional movement of multimeric protein particles, termed IFT particles, between the cell body and the distal tip of a flagellum. IFT particle proteins are thought to serve as scaffolds to facilitate the attachment of cargo proteins to IFT motors, mediating the transport of flagellar precursors []. The main constituents of IFT particles are organized into two protein complexes, A and B.IFT25 is a component of the intraflagellar transport (IFT) complex B. It directly interacts with IFT27, forming a subcomplex that may be involved in the regulation of IFT [, ]. IFT25 is required for Hedgehog signalling in cilia [].
IFT27, also known as RabL4 (Rab-like4), is a small GTPase-like component of the intraflagellar transport (IFT) complex B that promotes the exit of the BBSome complex from cilia via its interaction with ARL6 []. It is capable of forming a heterodimer with IFT25 (HSPB11) [, ]and is involved in the hedgehog (Hh) signaling pathway [].
