The alternative splicing of the ILF3 gene generates two ubiquitous proteins, interleukin enhancer binding factor 3 (Ilf3) and Nuclear Factor 90 (NF90). They have an identical N-terminal domain of 701 amino acids and a specific C-terminal domain of 210 and 15 amino acids, respectively. They are double-stranded RNA-binding proteins implicated in mRNA metabolism []. NF90 and its isoforms are involved in transcription, translation, mRNA export and microRNA biogenesis. They are involved in DNA and RNA virus replication [].
