Innate immunity activator protein (INAVA) is required for optimal MAPK and NF-kappaB activation, cytokine secretion, and intracellular bacterial clearance. Genetic variations in INAVA are associated with an increased risk of inflammatory bowel disease []. Homologues are known from chordates.
This entry includes INAVA and CCDC120.Coil-coiled domain-containing protein 120 (CCDC120) was first identified as a centrosome protein []. Later, it was found to interact with cytohesin-2 to regulate vesicular trafficking and neurite growth []. It is part of the centriole subdistal appendages (SDAs) that anchor microtubules in interphase cells [].Innate immunity activator protein (INAVA) is required for optimal MAPK and NF-kappaB activation, cytokine secretion, and intracellular bacterial clearance. Genetic variations in INAVA are associated with an increased risk of inflammatory bowel disease []. Homologues are known from chordates.
