Inscuteable (Insc) is a key regulator of spindle orientation in asymmetric divisions in both Drosophila and mammals [, ]. Insc is a competitive interactor of LGN [, ].
This entry represents the C-terminal region of protein Inscuteable (Insc) containing four putative armadillo repeats and the conserved extreme C-terminal tetrapeptide Glu-Ser-Phe-Val which is in agreement with the class I PDZ-binding motif X-Ser/Thr-X-/ (X and / are unspecified and hydrophobic residues, respectively). Insc functions as an adaptor protein that binds simultaneously with Partner of Insc (Pins, consisting of alpha subunit (Ga) of heterotrimeric G proteins and its guanine nucleotide dissociation inhibitor) and Par3 (PDZ-containing proteins) to regulate their apical localisation in neuroblasts, which is required for the correct execution of the asymmetric division [, ].
