INTS14 is part of the integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing [, ].
This entry represents the C-terminal α-helical domain of Integrator complex subunit 14 (IntS14) [], a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5 []. IntS14 interacts with IntS13; both of them consist of an N-terminal VWA domain () followed by a central β-barrel domain () and a C-terminal α-helical domain, which are connected through a linker devoid of secondary structure elements. This domain contribute to binding by packing against the β-barrel of IntS13 [].
This entry represents the central β-barrel domain of Integrator complex subunit 14 (IntS14), a component of the integrator complex which is involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box-dependent processing. This complex is also involved in the 3'-end processing of the U7 snRNA, and the spliceosomal snRNAs U1 and U5 []. IntS14 interacts with IntS13, both of them consist of an N-terminal von-Willebrand type A like domain (VWA, ), followed by a central β-barrel domain (this entry) and a C-terminal α-helical domain () connected through a linker. The interface involves all domains of both proteins, both β-barrel domains form the centre of the complex and contribute to the major contact between Ints13-IntS14 [].
