This entry includes yeast Isy1 and it's homologues from plants and animals. In budding yeast, Isy1 is part of the NineTeen Complex (NTC), which is involved in spliceosome activation by specifying the interaction of U5 and U6 with pre-mRNA for their stable association with the spliceosome after U4 dissociation []. The S. pombe homologue is known as Cwf12.
This entry includes yeast Isy1 and it's homologues from plants and animals. In budding yeast, Isy1 is part of the NineTeen Complex (NTC), which is involved in spliceosome activation by specifying the interaction of U5 and U6 with pre-mRNA for their stable association with the spliceosome after U4 dissociation []. The S. pombe homologue is known as Cwf12.
This domain superfamily is found in uncharacterised protein whose genomic location within nitrogen fixation clusters suggests that they may play a role in this process. They consist of two α-helices. A four-residue linker between the helices allows them to form an anti-parallel bundle and cross over each other towards their termini []. A similar domain is found in Sulfolobus spindle-shaped virus 1 (SSV1) protein D-63 []. This domain is also present in eukaryotic proteins such as Golgi to ER traffic protein 1 (GET1), also known as tail-anchored protein insertion receptor WRB, Pre-mRNA-splicing factor ISY1 and Vacuolar protein sorting-associated protein 37.
