This entry represents the BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain, also known as tetramerization (T1) domain, found in KCTD15 proteins from vertebrates. It is a versatile protein-protein interaction motif that facilitates homodimerization or heterodimerization. The BTB domains from KCTD family members can adopt a wide range of oligomerization geometries, including homodimerization, tetramerization, and pentamerization. The KCTD1 BTB domains, closely related to KCTD15, form pentamers [, ].BTB/POZ domain-containing protein KCTD15 (potassium channel tetramerization domain-containing protein 15) plays a role in the regulation of neural crest (NC) formation and other steps in embryonic development. It inhibits AP2 transcriptional activity by interacting with its activation domain [, , ].
