This domain of unknown function is found N-terminal in Lysine-specific demethylase 3A/B (KDM3A/B, also known as JmjC domain-containing histone demethylation protein 2A/B or JHDM2A/B) and related sequences. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 []. This enzyme plays a central role in histone code. This domain is predicted to adopt an open ��-barrel with an SH3-like topology.
This domain is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B), Lysine-specific demethylase 3A (KDM3A, also known as JmjC domain-containing histone demethylation protein 2A or JHDM2A) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 []. This enzyme plays a central role in histone code. This domain is predicted to adopt an open ��-barrel with an SH3-like topology. It has significant sequence and structural similarity to RDM15 tudor domain that is known to specifically recognise the monomethylation (H3K4me1) mark of lysine at position 4 of histone H3 [].
This domain is found in Lysine-specific demethylase 3B (KDM3B, also known as JmjC domain-containing histone demethylation protein 2B or JHDM2B), Lysine-specific demethylase 3A (KDM3A, also known as JmjC domain-containing histone demethylation protein 2A or JHDM2A) and related proteins. KDM3B is a histone demethylase that specifically demethylates lysine at position 9 of histone H3 []. This enzyme plays a central role in histone code. This domain is predicted to adopt an open ��-barrel with an SH3-like topology. It has detectable sequence and structural similarity to PWWP reader domains of LEDGF and ZMYND8 known to recognise the histone H3 methylation marks of lysine at position 36.
