Kinesin-like protein KIF22 (also known as kinesin-like DNA-binding protein, Kid) is a chromokinesin that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis [, , ]. KIF22 is associated with chromosome arms and plays an important part in producing the polar ejection forces that move chromosome arms toward the spindle equator at metaphase during mitosis []. Its destruction is needed for anaphase chromosome movement []. Depletion of KIF22 caused abnormal chromosome arm orientation, delayed chromosome congression, and sensitised cells to nocodazole []. Defects in KIF22 are the cause of spondyloepimetaphyseal dysplasia with joint laxity, type 2 (SEMDJL2), a bone disease characterised by short stature, distinctive midface retrusion, progressive knee malalignment, generalised ligamentous laxity, and mild spinal deformity [, ].
