Krueppel-like factor 1 (KLF1 or EKLF) is a transcription factor that globally activates genes involved in erythroid cell development . It belongs to the KLF family of transcription factors that binds the G-rich strand of so-called CACCC-box motifs located in regulatory regions of numerous erythroid genes []. It regulates erythroid lineage commitment, globin switching, and the terminal maturation of red blood cells. Mutations in the KLF1 gene have been associated with microcytic hypochromic anemia and increased fetal hemoglobin [].
