This entry represents the first malignant brain tumour (MBT) unit found in Lethal(3)malignant brain tumour-like protein 3 (L3MBTL3) from vertebrates. L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It functions by recruiting the histone demethylase KDM1A to Notch-responsive elements, promoting H3K4me demethylation []. Furthermore, L3MBTL3 regulates the ubiquitin-dependent degradation of methylated non-histone proteins, including SOX2, DNMT1, and E2F1, acting as an adapter that recruits the CRL4-DCAF5 E3 ubiquitin ligase complex to these methylated targets [, ]. L3MBTL3 is also essential for the normal maturation of myeloid progenitor cells [, , , , , ]. This entry typically co-occurs with two other MBT units, a C2H2C-type zinc finger, and a sterile alpha motif (SAM) domain.
This entry represents the third malignant brain tumour (MBT) unit found in lethal(3)malignant brain tumour-like protein 3 (L3MBTL3). L3MBTL3 acts as a negative regulator of Notch target gene expression and is required for RBPJ-mediated transcriptional repression []. It is also involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1 [, ]. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins. L3MBTL3 typically contains three MBT units, along with a SAM domain and a C2H2C-type zinc finger [, , ].
