This entry corresponds to the C-terminal region of LAMB1 found in chordata only. This region is involved in the integrin binding activity.LAMB1 is also called laminin B1 chain, laminin-1 subunit beta, laminin-10 subunit beta, laminin-12 subunit beta, laminin-2 subunit beta, laminin-6 subunit beta, or laminin-8 subunit beta. It is a glycoprotein that is involved in the pathogenesis of neurodevelopmental disorders. It also plays a crucial role in both lung morphogenesis and physiological function. Mutations in LAMB1 are associated with Cobblestone brain malformation (COB) with variable muscular or ocular abnormalities. LAMB1 is a component of laminin, a complex glycoprotein consisting of three different polypeptide chains (alpha, beta, gamma). Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components [, , , , , , ].
This domain is found in human Laminin subunit beta-1/2/3/4 (LAMB1-4) and related proteins from animals. LAMB1 is thought to mediate the attachment, migration and organisation of cells into tissues during embryonic development by interacting with other extracellular matrix components []. This domain, which is located C-terminal to multiple Laminin EGF domains (), is predicted to adopt a mainly ��-helical fold.
