Lasp1 (LIM and SH3 domain protein 1) is a cytoplasmic protein that binds focal adhesion proteins and is involved in cell signaling, migration, and proliferation []. It is overexpressed in several cancer cells, including breast, ovarian, bladder, and liver [, , ]. In some cancer cells, it can be found in the nucleus; its degree of nuclear localization correlates with tumour size and poor prognosis []. Lasp1 is a 36kDa protein containing an N-terminal LIM domain, two nebulin repeats, and a C-terminal SH3 domain []. This entry represent the SH3 domain.
