LEM domain-containing protein 2 (LEMD2 or LEM2) is an inner nuclear membrane protein associated with A-type lamins that is involved in nuclear structure organization [, ]. It also plays a role in embryonic development and in the regulation of several signaling pathways [].LEM2 contains an N-terminal LEM domain, two putative transmembrane domains and a MAN1-Src1p C-terminal (MSC) domain, but lacks the Man1-specific C-terminal RNA recognition motif (RRM) [].
