This entry includes Liat1 (ligand of Ate1) from animals. Liat1 interacts with Ate1 and may be involved in Ate1-mediated N-terminal arginylation. Ate1 is a component of the N-end rule pathway, which recognizes and polyubiquitylates proteins containing N-terminal degradation signals, targeting them for degradation by the proteasome.In primates, Liat1 genes are subtelomeric and Liat1 protein contains tandem repeats of a 10-residue sequence, whereas Liat1 proteins of other mammals contain a single copy of this motif [].
